Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain
By Michelle onPublished: Pathogenic mutations in LRRK2 are known to cause loss of primary cilia in neurons. The authors show that cilia loss is seen very early in mice harboring the most common LRRK2 mutation. Further, they show that this loss of cilia in astrocytes disrupted signaling pathways required for dopamine neuron maintenance. View original preprint.
Structural basis for the specificity of PPM1H phosphatase for Rab GTPases
By Michelle onPublished: LRRK2 acts by adding a phosphate group to enzymes known as Rab GTPases, which causes new biological events. The authors analyzed the structure of an enzyme, PPM1H, that counteracts LRRK2 by removing the phosphate group it adds to Rab GTPases. View original preprint.
High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s disease
By Blythe Lloyd onPublished: This article compared blinded cerebrospinal fluid (CSF) samples for a randomly selected subset of PPMI subjects (30 PD, 30 HC, and 20 SWEDD) and analyzed each in parallel using different αSyn-SAA protocols to understand the reproducability of aSyn-SAA as a diagnostic tool.
LRRK2 at Striatal Synapses: Cell-Type Specificity and Mechanistic Insights
By Blythe Lloyd onReview: This review focuses on pathogenic LRRK2 mutations and their effects on striatial neurons.
