A single-cell atlas of cell types, states, and other transcriptional patterns from nine regions of the adult mouse brainon
We report 690K single-cell transcriptomes from nine different brain regions from adult mice (Frontal and Posterior Cortex, Hippocampus, Thalamus, Cerebellum, Striatum, Globus Pallidus externus/Nucleus Basalis, Entopeduncular / Subthalamic Nuclei, & Substantia Nigra / Ventral Tegmental Area).
Peripheral neuronal activation of the intestinal tract shapes the microbiome and alters gut physiology-RNAseqon
This RNA data set corresponds to the preprint: Neuronal Activation of the Gastrointestinal Tract Shapes the Gut Environment in Mice (Yoo et al., 2021).
Primary data associated with doi: 10.7554/eLife.67900 (Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain)on
Immunofluorescence microscopy images, raw immunoblotting data and tabular data used to generate graphs shown in all figures.
Primary data associated with doi: 10.15252/embr.202152675 (Structural basis for the specificity of PPM1H phosphatase for Rab GTPases. EMBO Rep. 2021 Nov 4;22(11):e52675)on
Raw immunoblotting data; scans of Coomassie-stained SDS-PAGE gels; tabular data for quantifications; list of cross-links with distances; numerical data for in vitro assays; data files from Astra Software analysis.
Mass spectrometry proteomic data supporting the PPM1H/Rab8A crosslinking study described in doi: 10.15252/embr.202152675on
Mass spectrometry proteomic data supporting the PPM1H/Rab8A crosslinking study described in doi: 10.15252/embr.202152675, deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD026367
Primary data associated with Figure 3–Figure Supplement 4 in doi: 10.1101/2022.04.25.489459on
Raw immunoblotting data and tabular data for quantitation used to generate Figure 3–Figure Supplement 4 in doi: 10.1101/2022.04.25.489459 ("A Feed-forward Pathway Drives LRRK2 kinase Membrane Recruitment and Activation").
Primary data associated with doi: 10.1101/2022.04.25.489459 (A Feed-forward Pathway Drives LRRK2 kinase Membrane Recruitment and Apparent Activation)on
Raw immunoblotting data; tabular data for quantifications; immunofluorescence images.
Primary data associated with doi: 10.1042/BCJ20220308 (PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain)on
Raw immunoblotting data; immunofluorescence microscopy images; tabular data for quantification; autoradiograph films; scans of Coomassie-stained protein gels; Prism files with statistical analysis.
Primary data associated with doi: 10.1042/BCJ20220161 (Impact of 100 LRRK2 variants linked to Parkinson’s Disease on kinase activity and microtubule binding)on
Raw immunoblotting data; tabular data for quantifications; numerical data for in vitro assays; immunofluorescence images; Prism files for statistical analysis.
Crystal structure of Wild-Type PPM1H phosphataseon
Crystal structure of WT PPM1H phosphatase (as reported in 10.15252/embr.202152675) deposited in the Protein Data Bank with code 7L4J.
The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lineson
The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines. Associated with publication 10.1101/2022.06.01.494130.
Data set of the manuscript “Neuronal hyperactivity-induced oxidant stress promotes in vivo a-synuclein brain spreading”on
Data set of the manuscript "Neuronal hyperactivity-induced oxidant stress promotes in vivo a-synuclein brain spreading".
Basal ganglia neurons in healthy and parkinsonian primates generate recurring sequences of spikes (Dataset)on
The data are interspike interval measurements generated from electrophysiological recordings of spontaneous spiking activities of single neurons in the basal ganglia of awake monkeys, before and after rendering them parkinsonian by treatment with MPTP. The animals were not engaged in any task or other structured activity.
Bulk NGS/allele quantification – Highly efficient generation of isogenic pluripotent stem cell models using prime editingon
This file contains sequencing results for amplicons covering specific regions of interest related to prime editing of hPSCs.
Highly efficient generation of isogenic pluripotent stem cell models using prime editing – Datasetson
This collection contains the following datasets related to the paper "Highly efficient generation of isogenic pluripotent stem cell models using prime editing." 1. AAVS1 knock-in genotyping 2. aCGH karyotyping 3. Tabular datasets for associated graphical figures
Tomogram data of TauRD-Y forms amyloid-like aggregates in cellson
Tomograms: The tomograms shown in Fig. 1d and Fig. 3c are available in the EMDB https://www.ebi.ac.uk/emdb/ through the following information: EMD ID: EMD-13739 (Fig. 1d) and EMD-13740 (Fig. 3c) https://www.ebi.ac.uk/emdb/EMD-13739 https://www.ebi.ac.uk/emdb/EMD-13740 Associated with the following preprint: Saha et al., 2022 (published on biorxiv on Feb 19th, 2022) https://www.biorxiv.org/content/10.1101/2022.02.18.481043v1.full
Genome-wide determinants of mortality and clinical progression in Parkinson’s disease – Summary statistics (Dataset)on
Summary statistics from "Genome-wide determinants of mortality and clinical progression in Parkinson’s disease". medRxiv: https://www.medrxiv.org/content/10.1101/2022.07.07.22277297v1
Membrane tube assay data for Jensen et al, 2022
Damaged mitochondria recruit the effector NEMO to activate NF-κB signalingon
All datasets associated with the "Damaged mitochondria recruit the effector NEMO to activate NF-κB signaling" article. DOI:10.1101/2022.06.21.496850
Raw tomogram of GFP-a-synuclein inclusion in primary mouse neuron expressing GFP-a-synuclein, seeded with PFFson
Raw data associated with DOI: 10.1038/s41467-021-22108-0