Dataset Archive

The Human Postmortem-Derived Brain Sequencing Collection is a harmonized repository comprised of sequencing data contributed by ASAP CRN teams.

Mass spectrometry proteomics data associated with "Temporal landscape of mitochondrial proteostasis governed by the UPRmt" deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD038403.

DAT-Cre mice with a nuclear GFP reporter and either WT or heterozygous G2019S mutant alleles for the gene Lrrk2. Samples contain tissue from midbrains after isolation of DAT+ nuclei via microfluidic sorting for GFP.

The files found here are associated to Nebuloni, F. et al. (2024) study and contains: (a) all source and supplementary data and (b) key resources table.

This zenodo record contains the raw data for the preprint including raw data csv files, images, matlab codes, imageJ macros, and Prism analysis files. See the README files for more details.

Raw data Manuscript Wouters et al BBA 2023.

This protocol details the maintenance and differentiation of SHSY-5Y neuroblastoma cells.

Dataset collection related to preprint, "LRRK2-G2019S Synergizes with Aging and Low-Grade Inflammation to Promote Gut and Peripheral Immune Cell Activation that Precede Nigrostriatal Degeneration."

Comparative gene expression profiling analysis of RNA-seq data for DAT-TRAP samples in 3- and 18-month old mice, with and without human alpha-synuclein overexpression.

Study includes various image sets: Duplex-1&2, amyloid fibril, TEM fibril, DLS, SMLM 1&2, CLEM, FIB SEM, live-cell, superoxide, MitoTracker, TMRM, Ca2+, NADH, cell death, Amytracker, cardiolipin, and FRET images.

Structural conversion of α-synuclein at the mitochondria induces neuronal toxicity; image data.

The current study shows dynamic changes in α-synuclein levels in the basolateral amygdala (BLA) circuits, impacting social behavior. Chemogenetic stimulation of cortico-BLA inputs can rescue impaired behavior, suggesting potential therapies.

Raw immunocytochemistry images and quantification of CASR expression in mouse brain slices.

This dataset contains four 3-month old mouse samples and four 18-month old mouse samples. Of each group, the genotype of half samples is wild-type while that of the rests is OVX (human alpha-synuclein overexpression).

Primary data (RNA sequencing; microscopy & imaging) associated with the manuscript, "Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s disease" (doi: 10.1073/pnas.2402206121).

Source data - Cortical PFFs for motor cortical neuronal hyperexcitability associated with α-Synuclein aggregation.

Datasets from Simmons et al 2024.

In this study, the authors proposed a semi-automated DNA extraction protocol for human salivary samples collected with a commercial kit, and compared the outcomes with the DNA extraction recommended by the manufacturer.

Cell_by_gene and Cell_metadata files from MERFISH runs of mouse Midbrain spatial transcriptomics. Datasets are set up to be analyzed using Seurat v5.

The authors present a suite of open source, customizable head fixation designs with standard variants including head-fix hardware as well as implant protection systems.