Dataset Archive

Source data for publication: "Ca2+ channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons."

Datasets for all figures 1-8 in: GABAergic regulation of striatal spiny projection neuron excitability depends upon their activity state Image is taken from Fig 1B inset and illustrates RiboTag-eGFP in SPNs of the striatum.

Datasets for all supplementary figures S1-4 in GABAergic regulation of striatal spiny projection neuron excitability depends upon their activity state (2023).

To characterize the dysbiosis at species, gene family, and metabolic pathway resolution, the authors enrolled 490 PD and 234 age and geographically matched neurologically healthy individuals, collected stool and metadata, and conducted deep shotgun metagenomic sequencing of fecal DNA. Sequences and metadata are provided here.

Classification: PROTEIN FIBRIL Organism(s): Homo sapiens Expression System: Escherichia coli BL21(DE3) Mutation(s): No

Classification: PROTEIN FIBRIL Organism(s): Homo sapiens Expression System: Escherichia coli 'BL21-Gold(DE3)pLysS AG Mutation(s): No

Classification: PROTEIN FIBRIL Organism(s): Homo sapiens Expression System: Escherichia coli 'BL21-Gold(DE3)pLysS AG Mutation(s): No

Classification: PROTEIN FIBRIL Organism(s): Homo sapiens Expression System: Escherichia coli 'BL21-Gold(DE3)pLysS AG Mutation(s): No

Classification: PROTEIN FIBRIL Organism(s): Homo sapiens Expression System: Escherichia coli BL21(DE3) Mutation(s): No

Classification: PROTEIN FIBRIL Organism(s): Homo sapiens Expression System: Escherichia coli 'BL21-Gold(DE3)pLysS AG Mutation(s): No

Classification: PROTEIN FIBRIL Organism(s): Homo sapiens Expression System: Escherichia coli 'BL21-Gold(DE3)pLysS AG Mutation(s): No

Classification: PROTEIN FIBRIL Organism(s): Homo sapiens Expression System: Escherichia coli 'BL21-Gold(DE3)pLysS AG Mutation(s): No

Classification: PROTEIN FIBRIL Organism(s): Homo sapiens Expression System: Escherichia coli 'BL21-Gold(DE3)pLysS AG Mutation(s): No

Classification: PROTEIN FIBRIL Organism(s): Homo sapiens Expression System: Escherichia coli 'BL21-Gold(DE3)pLysS AG Mutation(s): No

Classification: PROTEIN FIBRIL Organism(s): Homo sapiens Expression System: Escherichia coli 'BL21-Gold(DE3)pLysS AG Mutation(s): No

From the brain, cortex, hippocampus, ventral midbrain, and striatum were taken to examine both global and regionally-specific transcriptomic perturbances that emerge in response to gut leakiness. All tissues were assayed with high-throughput RNA sequencing.

Raw band intensity values used for the quantification of in vitro LC3 lipidation results (Fig4C) in Three-step docking by WIPI2, ATG16L1 and ATG3 delivers LC3 to the phagophore.

Raw band intensity values used for the quantification of percentage autophagy levels.

To identify the signaling pathways that underlie the motor learning deficits, specifically in the RC mice, the authors performed six-plex tandem mass tag (TMT) quantitative mass spectrometry (MS) to compare the protein expression of either RC or GS and WT mice following the five days of the rotarod test.

The tabular data of fast-scanning cyclic voltammetry and physiology experiments from manuscript: "R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations." by Xenias et al.