Behavioral screening defines three molecular Parkinsonism subgroups in Drosophila
By onWe created a new collection of 24 genetically well-controlled Drosophila models of familial forms of parkinsonism. Using unbiased behavioral screening and machine learning we identified three clusters of mutants that converge.
Microbiome-based biomarkers to guide personalized microbiome-based therapies for Parkinson’s disease
By onAddressing biomarkers in PD, researchers propose using the gut microbiome to guide patient selection for clinical trials. By identifying dysbiotic features, they aim to personalize treatments and improve success rates in disease-modifying therapies.
Cortico-amygdala synaptic structural abnormalities produced by templated aggregation of α-synuclein
By onPD and DLB involve α-syn inclusions in the amygdala affecting cognition and emotions. Cortico-amygdala synapses with α-syn aggregates show increased volume of synapses, potentially contributing to behavioral impairments.
Dissociation of putative open loop circuit from ventral putamen to motor cortical areas in humans I: high-resolution connectomics
By onHigh-resolution connectomics in human participants provides evidence for a non-canonical circuit linking the limbic ventral putamen to the motor cortex. These data are in line with previous findings in nonhuman primates.
Temporal control of acute protein aggregate turnover by UBE3C and NRF1-dependent proteasomal pathways
By onNeurodegenerative diseases involve proteostasis loss and protein aggregation leading to cell toxicity. Study reveals proteasome-dependent degradation of misfolded proteins, regulated by NRF1, UBE3C, and RPN13, impacting proteostasis in cells.
CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism
By onMutations in mitochondrial protein CHCHD2 lead to a form of Parkinson's disease. CHCHD2 T61I mutant mice show molecular changes in the brain, altered metabolism favoring glycolysis, and disrupted mitochondrial function in dopamine neurons.
Vibrational Control of Complex Networks
By onComplex networks' stability is crucial, but real-time control can be challenging. This paper proposes using vibrational control on network edges instead of nodes to stabilize systems, providing graph-theoretic conditions and effective design methods.
Parkinson’s Families Project: a UK-wide study of early onset and familial Parkinson’s disease
By onThe genetic variations in familial and early-onset Parkinson’s disease were studied. Most early-onset and familial PD cases do not have a known genetic cause, indicating that there are likely to be further monogenic causes for PD.
Progressive vulnerability of cortical synapses in α-synucleinopathy
By onα-Synuclein aggregation is linked to progressive loss of intracortical VGLUT1+ excitatory synapses, spares VGLUT2+ long-range synapses, and impairs cortical excitatory transmission.
Presynapses are mitophagy pit stops that prevent axon degeneration
By onDefective neuronal mitophagy is linked to PD. Damaged axonal mitochondria accumulate at presynapses, sites of mitophagy initiation and autophagosome formation. of receptor mediated mitophagy with Roxadustat, reveals a potential therapeutic avenue.
Comparative Analysis of AAV Serotypes for Transduction of Olfactory Sensory Neurons
By onThis study compared the efficacy and selectivity of 11 different AAV serotypes for the efficient and selective transduction of murine olfactory sensory neurons in vivo. The findings inform research approaches and gene therapy based initiatives.
Assembloid model to study loop circuits of the human nervous system
By onHuman stem cells are used to create in vitro cortico-striatal-thalamic-cortical circuits, mimicking neural networks involved in neuropsychiatric disorders. This system allows study of normal development and diseases like autism and Tourette syndrome.
Mitochondrial fission controls astrocyte morphogenesis and organization in the cortex
By onMitochondrial fission in astrocytes plays a key role in brain development. Loss of Drp1 disrupts mitochondrial distribution, leading to astrocyte morphological changes and organization disruptions, impacting neurodevelopment and Connexin 43 levels.
Cell-Type Resolved Protein Atlas of Brain Lysosomes Identifies SLC45A1-Associated Disease as a Lysosomal Disorder
By onA study identified novel lysosomal proteins in brain cell types, including SLC45A1 causing neurological disease by affecting lysosomal function and iron homeostasis. This work enhances understanding of lysosome biology in neurodegeneration.
Bridge-like lipid transfer protein 3A (BLTP3A) is associated with membranes of the late endocytic pathway and is an effector of CASM
By onThe bridge-like lipid transfer protein, BLTP3A/UHRF1BP1, anchors VAMP7-positive vesicles to lysosomes and acts as an effector of CASM potentially to aid in the repair or mitigation of lysosomal damage.
RGS10 Attenuates Systemic Immune Dysregulation Induced by Chronic Inflammatory Stress
By onRGS10, a key regulator of immune cells, is decreased in individuals with Parkinson's Disease. Its deficiency, especially in males, leads to inflammatory responses in peripheral and CNS immune cells, suggesting a role in immune dysregulation in PD.
A Protocol for Neuralized Murine Olfactory Organoids
By onThis manuscript describes the methodology to generate olfactory organoids from olfactory epithelium isolated from adult mice. These organoids contain both neuronal and non-neuronal cell types and have been kept in culture for up to 3 weeks.
Thalamic integration of basal ganglia and cerebellar circuits during motor learning
By onBasal ganglia and cerebellum are vital for motor control and learning. Our works shows thalamic neurons integrate signals from both regions, and show distinct movement-related activity which play a key role in motor learning and control in mice.
Single cell long read whole genome sequencing reveals somatic transposon activity in human brain
By onSingle cell long-read sequencing uncovers novel dynamics in three brains, shedding light on genomic variability. It reveals brain-specific transposable element activity, offering crucial insights into individual cell genomes.
The mitochondrial unfolded protein response promotes senescence in human microglia by increasing S-adenosylmethionine availability for polyamine synthesis
By onMitochondria have a response to stress called UPRmt, aiding proteostasis. In humans, UPRmt affects microglia, causing metabolic changes and disrupting communication, leading to dysfunction and inflammation, impacting brain aging and disease.
