Viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegeneration
By onNovel viral vector for α-syn overexpression, AAV-DIO-hASYNWT, can be expressed selectively in neuronal populations based on Cre. Overexpression in DANs did not cause degeneration. AAV-DIO-hASYNWT increased DA levels and locomotor hyperactivity.
Progressive noradrenergic degeneration and motor cortical dysfunction in Parkinson’s disease
By onThe article discusses clinical and preclinical studies that support the critical rolLC-NE neurodegeneration and motor cortical dysfunction in both motor and nonmotor deficits in Parkinsonian states.
⍺-Synuclein levels in Parkinson’s disease – Cell types and forms that contribute to pathogenesis
By onParkinson's disease is characterized by dopamine neuron loss and ⍺-synuclein aggregations in neurons. Research focuses on understanding the levels, modifications, and impact of ⍺-synuclein in brain cells, including non-neuronal cells.
Targeting mitophagy in neurodegenerative diseases
By onMitochondrial dysfunction is key in neurodegenerative diseases like Parkinson's and Alzheimer's. Enhancing mitophagy could be a new therapeutic approach, with USP30 inhibitors and PINK1 activators in phase I trials for potential disease modification.
Mediterranean Diet Adherence, Gut Microbiota and Parkinson’s Disease: A Systematic Review
By onHigh adherence to the Mediterranean diet may improve cognitive function and gastrointestinal symptoms in Parkinson's disease patients, possibly due to changes in gut microbiota. More research is needed to understand its effects on motor symptoms.
Consensus Guidance for Genetic Counseling in GBA1 Variants: A Focus on Parkinson’s Disease
By onThis review discusses the link between *GBA1* and PD, testing practicalities, and counseling approaches.
Glycolipids in Parkinson’s disease: beyond neuronal function
By onGlycolipid balance is crucial for normal body function and its disruption can cause diseases like Parkinson's. Understanding glycolipid pathways can help develop treatments for neurodegenerative diseases like PD.
