pFastBac_Dual_GST-TEV-EGFP-TBK1

By Elias Adriaenssens, PhD
View Published Lab Material

Output Details

Description
Plasmid for the expression and purification of GST-TEV-EGFP-TBK1 in Spodoptera frugiperda cells (Sf9). Internal reference: SMC1631
Tags
  • Autophagy
  • Human
  • Recombinant
  • TBK1
Team
Team Hurley
Program
Collaborative Research Network
Theme
PD Functional Genomics

Meet the Authors

  • User avatar fallback logo

    Elias Adriaenssens, PhD

    Key Personnel: Team Hurley, 

    Max F. Perutz Laboratories

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pFastBac_Dual_GST-TEV-mCherry-TBK1

Plasmid: Plasmid for the expression and purification of GST-TEV-EGFP-TBK1 in Spodoptera frugiperda cells (Sf9). Internal reference: SMC1631. Used for the expression and purification of mCherry labelled TBK1 (SMC Internal No.: 1675).

View Lab Material

A lipid transfer-dependent feedback loop activates ATG9A compartments in autophagy initiation

Phagophore formation requires ATG9, ATG2 and PI3KC3-C1. Authors show that ATG2 is crucial for PI3P appearance on ATG9A compartments with little PI, suggesting a lipid transfer-driven feedback loop supporting lipid transfer and ATG8 lipidation.

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Aligning Science Across Parkinson's
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