Head-fixed Lever-pushing Task in Mice

By Richard Roth, PhD, Fuu Jiun Hwang, PhD, Charlie J. Huang and Jun Ding, PhD
View Published Protocol

Output Details

Description
This protocol describes a head-fixed lever-pushing task used to study motor learning and memory in mice suitable for recording neuronal activity concurrently.
Identifier (DOI)
10.17504/protocols.io.eq2ly63pwgx9/v1
Tags
  • Behavior/Behavioral studies
  • Behavioral
  • Mouse model
Team
Team Surmeier
Program
Collaborative Research Network
Theme
Circuitry and Brain-Body Interactions

Meet the Authors

  • User avatar fallback logo

    Richard Roth, PhD

    Key Personnel: Team Surmeier, 

    Stanford University

  • User avatar fallback logo

    Fuu Jiun Hwang, PhD

    Key Personnel: Team Surmeier, 

    Stanford University

  • User avatar fallback logo

    Charlie J. Huang

  • User avatar fallback logo

    Jun Ding, PhD

    Collaborating PI: Team Surmeier, 

    Stanford University

Related Research

Thalamic integration of basal ganglia and cerebellar circuits during motor learning

Basal ganglia and cerebellum are vital for motor control and learning. Our works shows thalamic neurons integrate signals from both regions, and show distinct movement-related activity which play a key role in motor learning and control in mice.

View Article

Performing surgeries, Image processing and Analysis on Animals

This protocol details the experimental procedures on animals that includes the surgery, two-photon imaging, cued lever-pushing task and analysis includes movement behavior analysis, and PCA.

View Protocol

Sheng et al 2025 Raw data #2

This dataset contains raw two photon images, and calcium trace and behavior data from the paper Sheng et al 2025 "Activity-Dependent Remodeling of Corticostriatal Axonal Boutons During Motor Learning”.

View Dataset
View More Outputs
Aligning Science Across Parkinson's
Powered by  GDPR Cookie Compliance
Privacy Overview

This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.