6-OHDA mouse model of Parkinson’s disease

By Beatriz Elizabeth Nielsen, PhD and Chris Ford, PhD
View Published Protocol

Output Details

Description
This protocol describes the steps for generating a 6-hydroxy-dopamine (6-OHDA) mouse model of Parkinson's disease. Low or high doses of 6-OHDA are injected into the medial forebrain bundle to induce a partial or a more complete dopaminergic lesion respectively.
Identifier (DOI)
10.17504/protocols.io.81wgbxyjylpk/v1
Tags
  • 6-OHDA
  • Animal
  • Animal models
  • Mouse
Team
Team Edwards
Program
Collaborative Research Network
Theme
Circuitry and Brain-Body Interactions

Meet the Authors

  • Beatriz Elizabeth Nielsen, PhD

    Key Personnel: Team Edwards, 

    University of Colorado Anschutz Medical Campus

  • Chris Ford, PhD

    Collaborating PI: Team Edwards, 

    University of Colorado

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Videos from Alcacer et al., Cell Reports 2025

Video files from manuscript Abnormal hyperactivity of striatal ensembles encodes distinct dyskinetic behaviors revealed by high-resolution clustering, Alcacer et al., Cell Reports 2025.

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Levodopa treatment for low-dose 6-OHDA-treated mice

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View More Outputs
Aligning Science Across Parkinson's
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