Microglia differentiation from human pluripotent stem cells
Output Details
Description
Microglia are brain-resident macrophage, that plays an essential role in synaptic pruning during brain development, maintaining homeostasis and clearance. Microglia have been implicated as a major player in various neurodegenerative diseases and acquire a disease-associated phenotype. Here we implemented optimized protocols for generating microglia-like cells from human embryonic (ES) and induced pluripotent stem cells (iPSCs). To derive microglia-like cells, we used previously published protocols from van Wilgenburg et al., 2013 and Haenseler et al., 2017.
Identifier (DOI)
10.17504/protocols.io.14egnr8ezl5d/v1
