Key Personnel: Team Harper,
MPI
Assembly factors guide proteasome core particle (CP) formation. Cryo-EM shows chaperones and propeptides aiding in subunit addition order, stabilization and activation, shedding light on proteasome biogenesis and functions of assembly factors.
A data-driven molecular map of the DLPFC reveals distinct spatial domains and cell populations, offering insights into neuropsychiatric disorders. The study provides a roadmap for implementing spatial clustering approaches in the human brain.
Plasmid for expression of human ATG9-V836A mutant in mammalian cells
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