Part2 Raw data for: Lysosomal glucocerebrosidase is needed for ciliary Hedgehog signaling: A convergent pathway contributing to Parkinson’s disease

By Sreeja Nair, PhD
View Published Dataset

Output Details

Description
Raw data for Figure6 of the manuscript: Lysosomal glucocerebrosidase is needed for ciliary Hedgehog signaling: A convergent pathway contributing to Parkinson's disease
Identifier (DOI)
10.5281/zenodo.15801264
Tags
  • Microscopy - optical
Team
Team Alessi
Program
Collaborative Research Network
Theme
PD Functional Genomics

Meet the Authors

  • User avatar fallback logo

    Sreeja Nair, PhD

    Key Personnel: Team Alessi, 

    Stanford Medicine

Related Research

Lysosomal Glucocerebrosidase is needed for ciliary Hedgehog signaling: A convergent pathway to Parkinson’s disease

Loss of dopamine neurons in Parkinson's disease is linked to mutations in *LRRK2* and *GBA1*. Both mutations inhibit Hedgehog signaling, reducing production of neuroprotective factors. This reveals a common mechanism contributing to PD pathogenesis.

View Article

Mouse brain immunohistochemistry – colorimetric analysis

Protocol for colorimetric analysis of mouse brain immunohistochemistry is described.

View Protocol

Primary data2: Pathogenic LRRK2 mutations cause loss of primary cilia and Neurturin in striatal parvalbumin interneurons

*LRRK2* mutations lead to loss of primary cilia and Neurturin in striatal parvalbumin interneurons, as found in the manuscript.

View Dataset
View More Outputs
Aligning Science Across Parkinson's
Powered by  GDPR Cookie Compliance
Privacy Overview

This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.