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KOLF2.1 iPSCs AAVS1-NGN2
oniPSCs from a British Caucasian male, modified with NEUROG2 using CRISPR/Cas9 in AAVS1 locus. Contains mutations in ARID2 (p.Pro197Hisfs*12) and COL3A1 (p.Gly1176Ser). Derived from skin fibroblasts of a 55-59-year-old male.
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pACEBac1-PSMA1-PSMA2-PSMA3-PSMA4-PSMA5-PSMA6-PSMA7
onExpression plasmid for human proteasome subunits.
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pACEBac1-PSMB1-PSMB2-PSMB3-PSMB4-PSMB5-PSMB6-PSMB7-TEV-2xSTII
onExpression plasmid for human proteasome subunits.
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pACEBac1-PSMB1-PSMB2-PSMB3-PSMB4-TEV-2xSTII-PSMB5-PSMB6-PSMB7
onExpression plasmid for human proteasome subunits.
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α-Synuclein aggregation decreases cortico-amygdala connectivity and impairs social behavior in mice
onThe study suggests that early circuit modulation could be an effective approach to alleviate symptoms associated with α-Syn pathology, necessitating studies of functional consequences of α-Syn aggregation.
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Multifiber array fabrication and calibration
onThis protocol describes a multi-fiber photometry approach to track dopamine release in mice with high spatial and temporal resolution in multiple locations in the brain simultaneously.
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Targeted optogenetic stimulations
onThis protocol includes the steps for targeted optogenetic manipulation using a new micro-fiber array approach that measures and optogenetically manipulates local dynamics across multiple targeted locations simultaneously in behaving mice.
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Multi-color fiber array imaging
onThis protocol includes the steps for fiber array imaging setup and acquisition using a new micro-fiber array approach that measures and optogenetically manipulates local dynamics across multiple targeted locations simultaneously in behaving mice.
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Stereotaxic viral injections and array implantation
onThis protocol includes the stereotaxic viral injections and array implantation steps using a micro-fiber array approach that measures and optogenetically manipulates local dynamics across multiple targeted locations simultaneously in behaving mice.
