Computational analysis for “Comparative Analysis of AAV Serotypes for the Transduction of Olfactory Sensory Neurons” by Belfort and Jia et al. 2024

By Benjamin Belfort, BSc and Johnathan Jia, MSc
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Output Details

Description
Code used for single nuclear RNAseq data analysis in "Comparative Analysis of AAV Serotypes for the Transduction of Olfactory Sensory Neurons" by Belfort and Jia et al. 2024. Entry contains Jupyter notebooks and Python scripts used for each step of snRNAseq analysis starting from alignment and quantification to the downstream terminal fate probability using Palantir.
Tags
  • 10X Genomics
  • AAV (Adenoassociated Virus)
  • Animal models
  • Olfaction
  • Olfactory mucosa
  • snRNA-seq (Single-nuclear RNA-seq)
Team
Team Schlossmacher
Program
Collaborative Research Network
Theme
Circuitry and Brain-Body Interactions

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Related Research

Comparative Analysis of AAV Serotypes for Transduction of Olfactory Sensory Neurons

This study compared the efficacy and selectivity of 11 different AAV serotypes for the efficient and selective transduction of murine olfactory sensory neurons in vivo. The findings inform research approaches and gene therapy based initiatives.

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Single nucleus transcriptomic dataset of AAV-infected mouse OE

Single nucleus sequencing dataset from mouse murine olfactory epithelium exposed to 4 AAV serotypes via nasal lavage.The goal was to identify the best candidate for transduction of olfactory sensory neurons. Code is included with the dataset.

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Microscopy dataset for: Comparative Analysis of AAV Serotypes for Transduction of Olfactory Sensory Neurons

Imaging dataset for the manuscript "Comparative Analysis of AAV Serotypes for Transduction of Olfactory Sensory Neurons ", by Belfort, Jia et al., 2024.

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