Cx3cr1-cre;Ercc1-/fl mice

By Vinal Menon, PhD

Output Details

Description
Increased endogenous DNA damage and possibly senescence in microglia
Tags
  • Mouse
Team
Team Lee
Program
Collaborative Research Network
Theme
PD Functional Genomics

Meet the Authors

  • Vinal Menon, PhD

    Key Personnel: Team Lee, 

    University of Minnesota

Related Research

Zhai et al. 2025 Raw data

Data includes immunohistochemistry images, two-photon images of patched neurons, whole-cell recordings for somatic excitability and Sr2+-oEPSC, spine density imaging, ACh sensor imaging, and dendritic excitability linescan data.

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Simulated mouse primary motor cortex activity during control and decreased pyramidal tract neuron excitability in the parkinsonian condition

Sixteen files were collected from 4 sets of simulations, each with control and Parkinsonian conditions in rest and activated states. Parkinsonian M1 simulations showed reduced PT5B neuron excitability. Simulations lasted 4.3 seconds.

View Dataset

suny-downstate-medical-center/pd_m1_6ohda: M1_Control_6OHDA

Liqiang Chu et al found decreased excitability in these neurons in a Parkinson's mouse model. A simulation using NetPyNE was created to study the impact of the changed PT5B neuron on motor cortex spiking dynamics.

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View More Outputs
Aligning Science Across Parkinson's
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