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EMD-40658
Output Details
Description
#### Structure of human ULK1 complex core (2:1:1 stoichiometry)
Tags
- Autophagy
- Human
- Other
- Structural biology
Meet the Authors
Related Research
Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex
Authors determine cryo-EM structure of human ULK1C core and its complex with PI3KC3-C1. ULK1C core undergoes a rearrangement from 2:1:1 to 2:2:2 stoichiometry, suggesting a structural mechanism for autophagy initiation.
How Membrane Contact Sites Shape the Phagophore
Phagophores form membrane contact sites with organelles like the vacuole, ER, and lipid droplets. In situ imaging techniques, such as cryo-CLEM, provide valuable insights into these interactions, aiding in understanding autophagosome biogenesis.
EMD-40735
Structure of human ULK1 complex core (2:2:2 stoichiometry) of the ATG13(450-517) mutant