Key Personnel: Team Hurley,
Walter and Eliza Hall Institute of Medical Research
Mitophagy maintains mitochondrial health by degrading damaged mitochondria. TBK1 adaptors NAP1 and SINTBAD regulate OPTN-driven mitophagy initiation and NDP52-driven progression, balancing pathway activity for efficient functioning.
This protocol details generation of ATG3 KO HeLa cells stably expressing HaloTag-LC3B.
This protocol details the generation of stable ATG3-mCherry wild-type or mutant HeLa cells with HaloTag-LC3B using lentivirus.
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