In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson’s disease

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Output Details

Description
Collection of all datasets (Metabolomics, microscopy and behavioural data) included in the article entitled "In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson’s disease"
Identifier (DOI)
10.5281/zenodo.7075026
Team
Team Vila
Program
Collaborative Research Network
Theme
Circuitry and Brain-Body Interactions

Related Research

In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson’s disease

Humanized rodents with neuromelanin can develop Parkinson's symptoms. Reducing neuromelanin accumulation mitigates PD features, showing a link between NM levels and disease pathology.

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Zhai et al. 2025 Raw data

Data includes immunohistochemistry images, two-photon images of patched neurons, whole-cell recordings for somatic excitability and Sr2+-oEPSC, spine density imaging, ACh sensor imaging, and dendritic excitability linescan data.

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Autophagy detection assay

Autophagosome detection using Dojindo DAPRed dye and Lysotracker Green in neurons

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View More Outputs
Aligning Science Across Parkinson's
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