manuelatan/PD-survival-GWAS: Release 2.0

By Manuela Tan
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Output Details

Description
Code for PD progression survival GWAS to mortality, and Hoehn and Yahr stage 3 or greater (H&Y3+) to understand the determinants of mortality and motor progression in Parkinson’s disease.
Identifier (DOI)
10.5281/zenodo.7923843
Tags
  • APOE (Apolipoprotein E)
  • Clinical measures
  • FUMA (Functional Mapping and Annotation of GWAS)
  • GWAS
  • Meta-analysis
  • Mortality
  • Motor symptoms
  • PD progression
  • Risk loci
  • SNPs (Single Nucleotide Polymorphisms)
  • Survival analyses
  • Visualization
Team
Team Hardy
Program
Collaborative Research Network
Theme
PD Functional Genomics

Meet the Authors

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    Manuela Tan

Related Research

Genome-wide determinants of mortality and motor progression in Parkinson’s disease

The authors examined the impact of gene variants on mortality and cognitive impairment in PD. Only the non-Gaucher disease causing GBA PD risk variant E326K, of the known PD risk variants, was associated with progression in PD.

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Genome-wide determinants of mortality and clinical progression in Parkinson’s disease – Summary statistics

Summary statistics from "Genome-wide determinants of mortality and clinical progression in Parkinson’s disease."

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SNP Genotyping and ApoE Genotyping

Protocol outlines DNA extraction from blood, quality control, SNP, and APOE genotyping. Adapted from PRoBaND SNP Genotyping and ApoE Genotyping Protocol by Malek et al. for Parkinson's Disease study.

View Protocol
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