Data includes immunohistochemistry images, two-photon images of patched neurons, whole-cell recordings for somatic excitability and Sr2+-oEPSC, spine density imaging, ACh sensor imaging, and dendritic excitability linescan data.
Liqiang Chu et al found decreased excitability in these neurons in a Parkinson's mouse model. A simulation using NetPyNE was created to study the impact of the changed PT5B neuron on motor cortex spiking dynamics.
Sixteen files were collected from 4 sets of simulations, each with control and Parkinsonian conditions in rest and activated states. Parkinsonian M1 simulations showed reduced PT5B neuron excitability. Simulations lasted 4.3 seconds.
