Key Personnel: Team Harper,
MPI
Assembly factors guide proteasome core particle (CP) formation. Cryo-EM shows chaperones and propeptides aiding in subunit addition order, stabilization and activation, shedding light on proteasome biogenesis and functions of assembly factors.
Study aimed to find proteins interacting with mitophagy receptors NIX or BNIP3 by incubating NIX-GST or BNIP3-GST with HeLa cell lysate to identify binding partners.
We aimed to identify proteins that would be turned over upon artificial tethering of WIPI2 to the mitochondrial surface upon rapalog treatment.
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