Neurodegenerative diseases are linked to autophagy dysfunction causing harmful build-up of cellular waste. Neurons with Parkinson's mutation increase release of autophagic vesicles and exosomes, suggesting a protective response to chronic stress.
Data includes immunohistochemistry images, two-photon images of patched neurons, whole-cell recordings for somatic excitability and Sr2+-oEPSC, spine density imaging, ACh sensor imaging, and dendritic excitability linescan data.
Sixteen files were collected from 4 sets of simulations, each with control and Parkinsonian conditions in rest and activated states. Parkinsonian M1 simulations showed reduced PT5B neuron excitability. Simulations lasted 4.3 seconds.
