PET-CT related to “Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and parkinsonian motor deficits”

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Output Details

Description
PET-CT related to "Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and parkinsonian motor deficits"
Identifier (DOI)
10.18112/openneuro.ds005895.v1.0.0
Team
Team Vangheluwe
Program
Collaborative Research Network
Theme
PD Functional Genomics

Related Research

Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and Parkinsonian motor deficits

ATP10B, a lipid flippase in endosomes/lysosomes, is linked to Parkinson's disease. Knockdown in rats led to motor deficits, reduced dopamine levels, and loss of dopaminergic neurons. Human cell studies supported these findings.

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Zhai et al. 2025 Raw data

Data includes immunohistochemistry images, two-photon images of patched neurons, whole-cell recordings for somatic excitability and Sr2+-oEPSC, spine density imaging, ACh sensor imaging, and dendritic excitability linescan data.

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Autophagy detection assay

Autophagosome detection using Dojindo DAPRed dye and Lysotracker Green in neurons

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Aligning Science Across Parkinson's
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