Protein interaction network analysis for Mendelian diseases

Output Details

This protocol describes the steps to use experimentally validated human data to create a protein-protein interaction network (PPIN) based on disease causative genes. Network analysis (combination of topological functional analyses) will lead to the identification of biological processes relevant for disease and disease endophenotypes.

Tags
  • Phenotypic variability
  • Protein-protein interaction

Meet the Authors

  • User avatar fallback logo

    Nikoleta Vavouraki

  • James Tomkins, PhD

    Key Personnel: Team Wood

    University of Cambridge

  • User avatar fallback logo

    Eleanna Kara

  • User avatar fallback logo

    Henry Houlden

  • John Hardy, PhD

    Lead PI (Core Leadership): Team Hardy

    University College London

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    Marcus J. Tindal

  • Patrick Lewis, PhD

    Collaborating PI: Team Hardy

    Royal Veterinary College

  • Claudia Manzoni, PhD

    Key Personnel: Team Hardy

    University College London

Aligning Science Across Parkinson's
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