Standardised TruAI Automated Quantification of Intracellular Neuromelanin Granules in Human Brain Tissue Sections

Output Details

Published August 11, 2025

To standardise and automate the quantitation of human-unique neuromelanin granules in catecholamine neurons in post-mortem tissue sections from healthy individuals at different ages to understand any changes in these granules with age. The TruAI automated platform reliably quantifies individual neuromelanin granules in catecholamine neurons. Extraneuronal pigments are considerably smaller in size than intracellular neuromelanin, and intracellular neuromelanin changes its properties with age. The darkening and colour change of intracellular neuromelanin suggest an increase in eumelanin over time in healthy individuals. These changes can be reliably identified using the automated platform.
Identifier (DOI)
10.1111/nan.70033
Tags
  • Original Research

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