State-dependent GABAergic regulation of striatal spiny projection neuron excitability: NEURON + Python model of striatal projection neurons

By Vernon Clarke, PhD, William C. Surmeier and James Surmeier, PhD
View Published Code

Output Details

Description
This repository contains a NEURON + Python model of striatal projection neurons (or SPNs) designed to simulate the interaction between GABAergic and glutamatergic synaptic inputs.
Identifier (DOI)
10.5281/zenodo.10162264
Tags
  • Computer modeling
  • Mouse
  • Neural circuitry
  • Striatum
Team
Team Surmeier
Program
Collaborative Research Network
Theme
Circuitry and Brain-Body Interactions

Meet the Authors

Related Research

State-dependent GABAergic regulation of striatal spiny projection neuron excitability

Synaptic transmission mediated by GABAA receptors (GABAARs) in adult, principal striatal spiny projection neurons (SPNs) can suppress ongoing spiking, but its effect on synaptic integration at sub-threshold membrane potentials is less well…

View Article

Network analysis of α-synuclein pathology progression reveals p21-activated kinases as regulators of vulnerability

Misfolded α-synuclein accumulation in PD leads to pathogenic processes. We mapped α-synuclein pathology in mice to identify vulnerable regions and potential therapeutic targets, highlighting group II PAK inhibitors as promising for treating PD.

View Article

Simulations predict differing phase responses to excitation vs. inhibition intheta-resonant pyramidal neurons

This research highlights how cortical neurons respond differently to oscillatory inputs, impacting neuronal responses to network state shifts.

View Article
View More Outputs