Transgenic A53T mice have astrocytic a-synuclein aggregates in dopamine and striatal regions

By Cormac Peat, Glenda Halliday, PhD, Asheeta Prasad, PhD, Carolyn Sue, PhD, Jennifer Johnston, PhD, David Finkelstein, Clare Parish, PhD, Lachlan Thompson, PhD and Deniz Kirik, MD, PhD

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Description

This study aimed to determine whether astrocytes accumulate a-synuclein before or after neurons, the present study histologically assessed astrocytes and a-synuclein accumulation in the M83 A53T transgenic mouse model of Parkinson’s disease prior to significant neuronal a-synuclein accumulation.

Identifier (DOI)

10.1101/2025.01.09.632283

Tags

Animal models
Astrocytes
Immunofluorescence
M83 A53T transgenic mouse model
Microscopy
Reactive astrocytes

Team

Team Kirik

Program

Collaborative Research Network

Theme

PD Functional Genomics

Meet the Authors

Cormac Peat
Glenda Halliday, PhD

Co-PI (Core Leadership): Team Kirik, Team Vila, Team Edwards,

University of Sydney
Asheeta Prasad, PhD

Key Personnel: Team Kirik,

University of Sydney
Carolyn Sue, PhD

Collaborating PI: Team Kirik,

Neuroscience Research Australia
Jennifer Johnston, PhD

Co-PI (Core Leadership): Team Kirik,

NysnoBio
David Finkelstein
Clare Parish, PhD

Co-PI (Core Leadership): Team Kirik,

Florey Institute of Neuroscience and Mental Health
Lachlan Thompson, PhD

Co-PI (Core Leadership): Team Kirik,

Florey Institute of Neuroscience and Mental Health
Deniz Kirik, MD, PhD

Lead PI (Core Leadership): Team Kirik,

Lund University

Transgenic A53T mice have astrocytic a-synuclein aggregates in dopamine and striatal regions

Output Details

Meet the Authors

Cormac Peat

Asheeta Prasad, PhD

Carolyn Sue, PhD

David Finkelstein

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