Videos from Alcacer et al., Cell Reports 2025

By Cristina Alcacer and Andreas Klaus
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Output Details

Description
Video files from manuscript **Abnormal hyperactivity of striatal ensembles encodes distinct dyskinetic behaviors revealed by high-resolution clustering**, Alcacer et al., Cell Reports 2025.
Identifier (DOI)
10.5281/zenodo.15619965
Tags
  • 6-OHDA
  • Dyskinesia
  • In Vivo
  • Levodopa
  • Mouse
  • Parkinson's disease
Team
Team Surmeier
Program
Collaborative Research Network
Theme
Circuitry and Brain-Body Interactions

Meet the Authors

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    Cristina Alcacer

  • User avatar fallback logo

    Andreas Klaus

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Abnormal hyperactivity of specific striatal ensembles encodes distinct dyskinetic behaviors revealed by high-resolution clustering

L-DOPA-induced dyskinesia is a common issue in Parkinson's disease due to dopamine therapy. These findings show that ensembles of behavior-encoding D1- and D2-SPNs form new combinations of hyperactive neurons mediating specific dyskinetic movements.

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6-OHDA mouse model of Parkinson’s disease

Protocol for creating a Parkinson's disease mouse model using 6-OHDA involves injecting different doses into the brain to induce varying levels of dopaminergic damage.

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Levodopa treatment for low-dose 6-OHDA-treated mice

This protocol describes a one-week levodopa treatment for mice partially depleted of dopamine.

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