Macroautophagy degrades cellular macromolecules during nutrient stress, providing building blocks and remodeling the proteome. YIPF3 and YIPF4 are identified as receptors for Golgiphagy, crucial for eliminating Golgi membrane proteins.
During nutrient stress, macroautophagy is employed to degrade cellular macromolecules. The authors' results reveal that autophagic turnover prioritizes membrane-bound organelles for proteome remodeling during nutrient stress.