Mice with LRRK2 R1441C and PINK1 KO mutations were crossed to create double mutant lines: LRRK2 WT/PINK1 WT, LRRK2 RC/PINK1 WT, LRRK2 WT/PINK1 KO, and LRRK2 RC/PINK1 KO.
Dardarin/Lrrk2 regulates inflammation, protein processing, and autophagy. Mutations, like R1441G, linked to Parkinson's disease. LRRK2 flox-R1441G mice model the disease for research, showing normal phenotype until gene manipulation.
