-
Single cell eQTL mapping reveals convergent glial–neuronal risk architecture in Parkinson’s disease
onPopulation-scale, disease-context aware meta single-nucleus eQTLs mapping (N 1,197) in nine cell types from cortex and substantia nigra identifies 125 risk genes and cell types for PD GWAS signals.
-
-
CREsted: modeling genomic and synthetic cell-type-specific enhancers across tissues and species
onCREsted, a sequence-based deep learning model, analyzes genomic regulatory code, decodes enhancer grammar, and designs synthetic enhancers. It preprocesses single-cell data, models chromatin accessibility, and compares cell states across tissues.
-
EnvA-N2c-deltaG-H2B-HA-FlpO
onGenerated for anatomical anterograde tracing experiments by Columbia University Zuckerman Institute Molecular Tools Core Facility (RRID:SCR_026201).
-
FushikiA_etal_2024: PD Model Mice Study – v1.0 Code
onRepository offers tools for processing, analyzing, and visualizing data related to PD and dopaminergic neurons.
-
pAAVDJ-Ef1a-FDOI-mScarlet
onGenerated for anatomical tracing experiments by Columbia University Zuckerman Institute Molecular Tools Core Facility (RRID:SCR_026201).
-
A druggable ATP13A3–antizyme switch controls adaptive polyamine uptake in cancer
onCellular polyamine depletion for cancer treatment is hindered by compensatory uptake. ATP13A3, not ATP13A2, is the key polyamine importer affected by DFMO. Antizyme inhibits uptake by ATP13A3, suggesting a targetable strategy for cancer therapy.
-
Generation of DATcrePink1 Knockout Mice Expressing tdTomato in Dopaminergic Neurons
onProtocol details generation of DATcrePink1 mice expressing tdTomato in dopaminergic neurons. Covers Pink1 KO, HET, WT variants, animal housing, breeding, and genotyping procedures.
