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Swollen lysosomes grab Rabs for a CASM-free route to LRRK2 activation
onThis is a brief report on "ClC-7 links PIKfyve inhibition to Rab-dependent LRRK2 activity at lysosomes".
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Rise-and-fall dynamics reveal a molecular and cellular vulnerability axis in prion-like α-synuclein propagation: Mathematical Model
onPrion Network Model: Julia modeling code, paper-specific analysis scripts, and figure reproduction workflow for nonlinear alpha-synuclein spread .
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Coordinated spatial organization of basal ganglia structures revealed by dopamine subtype projectome mapping
onHere, we map the subtype-specific projections of DA subtypes across various target regions. These findings provide a refined framework for understanding basal ganglia function and dysfunction in PD.
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NHP microscopy images- Dataset 1
onSpatial distribution of molecular markers in the macaque subthalamic nucleus using fluorescent in situ hybridization
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Tissue processing and sectioning — Oscar Moreno Ramos and Divya Raj
onThis protocol describes mouse brain fixation, sucrose cryoprotection, freezing, and sectioning before immunofluorescence on free-floating sections
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NHP microscopy images- Dataset 2
onQuantification of cell numbers in adult macaque brain sections with FISH labelling of brain tissue using different markers.
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Human microscopy images
onFISH labelling of brain tissue using different markers in adult human brain sections.
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GolgiFold: A Structural Predictome of Human Golgi Protein Complexes
onThis paper reports a structural interactome for the Golgi apparatus.
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snRNA-seq Sex Validation & Stratified Integration Pipeline
onNextflow pipeline for snRNA-seq analysis that validates donor sex using XIST and chrY expression, removes mislabeled samples, performs quality control and ambient RNA correction, and integrates datasets using Harmony or scVI for Parkinson’s research.
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Alphafold predictions for GolgiFold Protein-Protein Interactions
onThis entry is all the pairwise Alphafold models in GolgiFold as a web viewer.
