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Release Notes – ASAP CRN Cloud
onSummary: Release notes for version 1.0.0 of CRN Cloud platform, released on June 25, 2024, detailing latest updates and enhancements.
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Proteome Landscapes Decode Organelle Vulnerabilities in cortical and dopaminergic-like induced neurons Across Lysosomal Storage Disorders
onLysosomal Storage Disorders impact lysosomal function and can be linked to Parkinson's Disease risk. LSD mutant cells show varied endolysosomal proteomes, with specific disruptions in neuronal cells.
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Leucine Rich Repeat Kinase 2: Pathways to Parkinson’s Disease
onResearch on LRRK2 in Parkinson's disease has advanced, revealing how mutations activate the kinase, phosphorylate Rab proteins, disrupt cell functions like Hedgehog signaling, and contribute to the disease. LRRK2 inhibitors show promise for therapy.
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Flow cytometry data related to ‘The lipid flippase ATP10B enables cellular lipid uptake under stress conditions’
onFlow cytometry data related to 'The lipid flippase ATP10B enables cellular lipid uptake under stress conditions'
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Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress
onCryo-ET showed protein aggregates, altered cristae, and reduced ribosome complexes in stressed mitochondria. Mitochondrial Hsp60 undergoes conformational changes to aid in protein folding, shedding light on mitochondrial proteostasis mechanisms.
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Lipid dynamics at membrane contact sites
onLipid building blocks in eukaryotes are mainly produced in the endoplasmic reticulum and moved to other organelles via vesicles or proteins at organelle contact sites. We review what is known.
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Quantification of Axonal Projections from Whole-Brain Slide Images
onQuantification of Axonal Projections from Whole-Brain Slide Images provides a standardized method for processing and analyzing immunofluorescence images of mouse brain sections to quantify axonal projections.
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IBA1 Immunochemistry on human paraffin sections
onIba1-specific Immunochemistry protocol on paraffin-embedded human brain sections
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Olympus Slideview VS200″ slide scanning
onBrief guide on the main steps to follow in order to scann a sample with the "Olympus Slideview VS200 slide scanner. Although examples for certain parameters are presented, each user should choose them based on the characteristics of their samples.
