Custom MATLAB scripts related to Zhang, Y. et al (2025) “An axonal brake on striatal dopamine output by cholinergic interneurons”

By Yanfeng Zhang, PhD and Stephanie Cragg, PhD
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Output Details

Description
This release contains MATLAB scripts written by Yan-Feng Zhang to predict how nicotinic receptors impact on dopamine transient *in vivo* during the dynamic tonic and multiphasic activity in cholinergic interneurons that is coincident with phasic activity in dopaminergic neurons.
Identifier (DOI)
10.5281/zenodo.14622173
Tags
  • Acetylcholine
  • Computer modeling
  • Dopamine
  • Mouse
Team
Team Cragg
Program
Collaborative Research Network
Theme
Circuitry and Brain-Body Interactions

Meet the Authors

Related Research

An axonal brake on striatal dopamine output by cholinergic interneurons

Depolarization of axons is crucial for triggering neurotransmitter release. Cholinergic interneurons and nicotinic receptors in the striatum interrupt this process, causing a temporary suppression of dopamine release.

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Immunocytochemistry of acute brain slices used in ex vivo voltammetry recordings

Protocol labels ChAT for cholinergic interneurons and TH for dopaminergic neurons in mouse brain slices. Immunofluorescence used post ex vivo voltammetry recordings on 300-µm thick slices.

View Protocol

Datasets and Key Resources Table used in Zang, Y. et al. (2025) “An axonal brake on striatal dopamine output by cholinergic interneurons”

This repository contains a 1) Key Resources Table with details on key resources and the persistent identifiers for protocols and code used and generated in this study; 2) Source Data Folder, and 3) Supplementary Data Folder.

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