Datasets associated with “Peripheral Neuronal Activation Shapes the Microbiome and Alters Gut Physiology”
Output Details
- Antemortem
- Cholinergic neurons
- Dopaminergic neurons
- Enteric nervous system
- In Vivo
- Metabolomics
- Metagenome
- Microbiome
- Mouse
- Proteomics
- RNA bulk
Meet the Authors
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Bryan B. Yoo
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Peter Thuy-Boun
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Kelly Weldon
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Collin Challis
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Michael J. Sweredoski
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Ken Y. Chan
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Taren M. Thron
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Gil Sharon
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Annie Moradian
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Gregory Humphrey
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Qiyun Zhu
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Justin Shaffer
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Dennis W. Wolan
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Pieter C. Dorrestein
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Rob Knight
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Viviana Gradinaru, PhD
Lead PI (Core Leadership): Team Gradinaru,
California Institute of Technology
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Sarkis Mazmanian
Co-PI (Core Leadership): Team Sulzer, Team Gradinaru,
California Institute of Technology
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Related Research
Peripheral neuronal activation shapes the microbiome and alters gut physiology
The authors specifically activate ChAT- or TH-expressing gut-associated neurons in mice and perform multi-omics, finding that subsets of peripherally-activated neurons differentially regulate the gut microbiome and host GI physiology.
Data and code for shotgun metagenomics associated with Moiseyenko et al. 2025
Data and scripts to retrieve and analyze shotgun metagenomic data of wild-type, Thy1-ASO, and Faecalibacterium prausnitzii-treated Thy1-ASO mice from Moiseyenko et al. (2025)
Fecal metagenomic sequencing data for PD patients and controls from Rush University Medical Center
Fecal metagenomic sequencing data associated with Boktor et al. (2023). This dataset includes samples from the Rush University Medical Center cohort.