Mutations in genes that regulate mitophagy are causative for neurological disorders including Parkinson’s. Here, the authors identify a novel stress response pathway activated by mitochondrial damage that regulates mitophagy in neurons.
Glucocerebrosidase is a lysosomal enzyme that catalyzes the hydrolysis of glucosylceramide (GlcCer), a membrane glyco-sphingolipid, to ceramide and glucose. This assay detects GBA activity by using a fluorogenic substrate that reacts with cell…
