Mutations in genes that regulate mitophagy are causative for neurological disorders including Parkinson’s. Here, the authors identify a novel stress response pathway activated by mitochondrial damage that regulates mitophagy in neurons.
The AI-directed Voxel Extraction (AIVE) segmentation strategy combines AI predictions with image electron signals to confidently segment membrane boundaries. Authors identify a new category of Membrane contact Sites named Mitochondrial Intrusions.
