The connections between molecular mechanisms like mitophagy and tissue-wide features like neuro-inflammation remain unclear. Here, the authors characterize a novel link between these two hallmarks of neurodegeneration.
The PD5D Atlas deciphers Parkinson's disease molecular blueprint using brain space, disease stage, and cell types dimensions. It includes various omics data and clinical scales to analyze PD progression from healthy aging to Lewy body neuropathology.
Allele-specific expression (ASE) analysis in single-nucleus RNA-seq (snRNA-Seq) helps study genetic variation impact on RNA expression. Experimental and computational choices can enhance ASE analysis results.
