The connections between molecular mechanisms like mitophagy and tissue-wide features like neuro-inflammation remain unclear. Here, the authors characterize a novel link between these two hallmarks of neurodegeneration.
Study aimed to find proteins interacting with mitophagy receptors NIX or BNIP3 by incubating NIX-GST or BNIP3-GST with HeLa cell lysate to identify binding partners.
Study aimed to find proteins degraded by DFP mimicking hypoxia-induced mitophagy. Identified proteins degraded after 24h DFP treatment, focusing on mitochondrial proteins.
