ASAP Parkinson Cell Atlas in 5D (PD5D)
Output Details
Description
The ASAP Parkinson Cell Atlas in 5D (PD5D) is a versatile discovery platform designed to overcome the gap from a 19th Century phenotypic view of Shaking Palsy to a molecular atlas of human Parkinson’s disease. The five dimensions of the atlas are: brain space (3D), disease stage (pseudo-time; 1D), and brain cell types (1D). PD5D provides a discovery platform for decrypting the molecular blueprint of PD and for elucidating the genetic variants, genes, cells, micro-anatomical niches, molecular programs, and their dynamic transitions at the onset and during the progression of PD. The atlas comprises multiomics assay modalities such as genotypes, single-nucleus RNAseq, Visium spatial transcriptomics, single-nucleus Atac-seq, as well as antemortem clinical cognitive and motor scales, postmortem neuropathology. The modalities are profiled with “temporal” dynamics across stage progression from healthy aging to the entire spectrum of Lewy body neuropathology from prodromal PD to advanced PD. They are also profiled with spatial dynamics from the onset of Lewy neuropathology in the brainstem (motor disease) to its crucial transition to the temporal cortex (cognitive disease; Lewy body dementia). PD5D is comprised of multiple data sets. The current data set represents the single-nucleus RNAseq data for the middle temporal cortex of 100 participants spanning healthy brains, and the entire spectrum of Lewy body neuropathology from prodromal PD to advanced PD.
Identifier (DOI)
10.5281/zenodo.8384742
