Preparation of human iPSC-derived cortical neuronal progenitors for transplantation into the rodent brain

By Louise Cottle, PhD and Clare Parish, PhD
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Output Details

Description
This protocol describes how we prepare human iPSC-derived cells, that have been differentiated into cortical neuronal progenitors, for transplantation into the brain of immunocompromised athymic mice. Neuronal progenitors mature within the mouse brain and are used to study the pathogenesis of Parkinson’s disease.
Identifier (DOI)
10.17504/protocols.io.x54v9ppeqg3e/v1
Tags
  • Cortical
  • hiPSCs (Human induced pluripotent stem cells)
  • Human-mouse xenograft model
  • Intracerebral transplantation
  • Neurons
Team
Team Kirik
Program
Collaborative Research Network
Theme
PD Functional Genomics

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