Single-cell transcriptomic and proteomic analysis of Parkinson’s disease Brains

By David Hafler, Sreeganga Chandra, PhD, Le Zhang, PhD, Biqing Zhu, Jae Min Park, BA, Sarah Coffey, I-Uen Hsu, TuKiet T. Lam, Pallavi P. Gopal, Stephen D. Ginsberg, Jiawei Wang, Cahng Su, Hongyu Zhao and Rui Chang, PhD

Published October 30, 2024

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Description

We provide an extensive single cell analysis profiling nearly 80,000 brain nuclei from prefrontal cortex of late-stage Parkinson’s disease brains, demonstrate that α-synuclein pathology is inversely correlated with chaperone expression in excitatory neurons, found a selective abatement of neuron-astrocyte interactions with enhanced neuroinflammation, and augmented the study with proteomic analysis and cross-comparisons with Alzheimer’s disease datasets, providing valuable insights into the pathways of neurodegeneration and a deep definition of the underlying molecular pathology for Parkinson’s disease.

Identifier (DOI)

10.1126/scitranslmed.abo1997

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