Dataset Archive

This data set includes different quantification parameters to identify the features of intracellular neuromelanin.

This dataset contains 224 paired fastq files (112 single cells) from the following samples: brains from two Multiple System Atrophy patients and one control, and non-brain controls (fibroblasts, NA12878).

Source data and images from the paper: Feed-forward metabotropic signaling by Cav1 Ca2+ channels supports pacemaking in pedunculopontine cholinergic neurons.

Primary data associated with the manuscript, "Genome-wide screen reveals Rab12 GTPase as 2 a critical activator of Parkinson’s disease-linked LRRK2 kinase."

Primary data associated with the manuscript, "Genome-wide screen reveals Rab12 GTPase as 2 a critical activator of Parkinson’s disease-linked LRRK2 kinase." These include raw immunoblotting data (.tiff files), annotated images (.pdf), and their quantitation and graphs obtained using GraphPad Prism(.pzf files). These also include microscopy images and their analyses in GraphPad Prism (.pzf files).

Confocal microscopy images, CellProfiler Excel files of Pearson's coefficients between TMEM55B/RILPL1 or pRab10/RILPL1 in R1441C MEF or VPS35 MEF cells, and Prism files of graphed Pearson's coefficients for each condition, as seen in doi: 10.1101/2023.06.07.544051.

Source data for Nature manuscript: Dynamic behavior restructuring mediates dopamine-dependent credit assignment.

Primary data associated with the manuscript "Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2" (Hanwen Zhu, Francesca Tonelli, Martin Turk, Alan Prescott, Dario R. Alessi, Ji Sun). These include immunoblotting data and their quantitation, representative confocal microscopy images, and quantitation and statistical analysis of confocal microscopy images.

Dataset corresponding to the article, "Peripheral MC1R activation modulates immune responses and confers neuroprotection in a mouse model of Parkinson's disease."

Dataset corresponding to the preprint, "Is Tau the Initial Pathology in Dopaminergic Nigrostriatal Degeneration? Studies in Parkinsonism and Parkinson’s Disease."

A dataset related to the development of human LC-NE neurons from human pluripotent stem cells.

Parkinson’s disease (PD) involves genetic and environmental risk factors. Research efforts have been made to understand how they interact to impair homeostasis and elevate risk. Inflammation could be one unifying factor. This dataset is related to a study that utilized a PD animal model to study the impact of inflammation.

With previous studies implicating the E-domain in clustering SVs, our experiments advocate a cooperative role for these two proteins in maintaining physiologic SV clusters. (https://elifesciences.org/reviewed-preprints/89687v1)

The experiments offer a new conceptual platform for investigating the role of Ser129 in synucleinopathies, with implications for drug development.

Raw data associated with each Figure and Supplementary Figures from "Novel green fluorescent polyamines to analyze ATP13A2 and ATP13A3 activity in the mammalian polyamine transport system."

In this study, the performance and biodistribution of the retrogradely-spreading AAV9-SynA53T vector was evaluated in the NHP brain. Conducted intraparenchymal deliveries of viral suspensions in the left putamen gave rise to a disseminated synucleinopathy in a circuit-specific basis.

Evidence has provided showing that intracellular aggregation of endogenous alpha-synuclein is triggered by NMel accumulation, therefore any therapeutic approach intended to decrease NMel levels may provide appealing choices for the successful implementation of novel PD therapeutics.

Our differentiation paradigm generates an efficient model for studying disease mechanisms in PD, and highlights that protein misfolding to generate intraneuronal oligomers is one of the earliest critical events driving disease in human neurons, rather than a late-stage hallmark of the disease.

This upload includes 1) ImageJ macros / scripts for minor automated cell counting for brain slides with immunostaining and 2) MATLAB functions / scripts for minor automated spine location cluster analysis (nearest neighbor distance / index).