Alpha-synuclein fibril from spontaneous control
By onProtein fibril from Homo sapiens expressed in Escherichia coli BL21-Gold(DE3)pLysS AG without mutations.
CryoEM structure of amplified alpha-synuclein fibril class B type I with extended core from DLB case X
By onProtein fibril classification for Homo sapiens using Escherichia coli 'BL21-Gold(DE3)pLysS AG expression system with no mutations identified.
CryoEM structure of amplified alpha-synuclein fibril class B type II with extended core from DLB case VII
By onProtein fibril from Homo sapiens expressed in Escherichia coli BL21-Gold(DE3)pLysS AG without mutations.
Proteome of R1441C and G2019S LRRK2 knock in mice after striatal motor learning task
By onTo identify the signaling pathways that underlie motor learning deficits, the authors performed six-plex tandem mass tag (TMT) quantitative mass spectrometry (MS) to compare the protein expression in mice following the five days of the rotarod test.
Tabular data associated with “Synapsin E-domain is essential for α-synuclein function”
By onDataset associated with the publication "Synapsin E-domain is essential for α-synuclein function."
Data associated with “Serine-129 phosphorylation of α-synuclein is a trigger for physiologic protein-protein interactions and synaptic function”
By onDataset associated with the publication "Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function."
Three-step docking by WIPI2, ATG16L1 and ATG3 delivers LC3 to the phagophore: Molecular dynamics simulation dat
By onAtomistic molecular dynamics simulation data set accompanying manuscript 10.1101/2023.07.17.549391.
Raw band intensity values for Halo-LC3B
By onSource values referred to raw band intensity used for the quantification of percentage autophagy levels.
Raw band intensity values for ATG3 WT or Mutants in vitro LC3 lipidation
By onRaw band intensity values used for the quantification of in vitro LC3 lipidation results (Fig4C) in 10.1101/2023.07.17.549391
Barnes et al (Preprint-03/24) – Datasets
By onDatasets connected to Barnes et al can be found in their preprint publication at https://doi.org/10.21203/rs.3.rs-3982325/v1.
Figure 2. Rubicon and Pacer RH domain have inverted pRAB7A binding specificity [FINAL]
By onFigure 2. Rubicon and Pacer RH domain have inverted pRAB7A binding specificity.
Figure 1: Rubicon KO Starvation and Mitophagy HaloTag processing assay
By onFigure 1. Rubicon depletion promotes bulk autophagy and Parkin mitophagy.
metabolomics data related to “Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease”
By onNeuromodulation such as deep brain stimulation is advancing as a clinical intervention in neurological and neuropsychiatric disorders, including Parkinson's disease. Here, the authors review current literature in the pre-clinical research fields.
MS proteomics data related to “Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease”
By onMS proteomics data related to "Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease" deposited to the MassIVE repository with the dataset identifier MSV000090202.
Data and code for “α-Synuclein Overexpression and the Microbiome Shape the Gut and Brain Metabolome in Mice”
By onMetabolomic data and analysis code associated with the article, "α-Synuclein Overexpression and the Microbiome Shape the Gut and Brain Metabolome in Mice."
Identification of phosphorylation sites on NAP1/AZI2
By onThe authors observed smearing for the TBK1-adaptor protein NAP1/AZI2 during mitophagy. Tthe authors performed an in vitro kinase assay and complemented this with the immunoprecipitation of NAP1, resulting in hyperactivation of TBK1.
Raw data of ‘The lipid flippase ATP10B enables cellular lipid uptake under stress conditions’
By onRaw data of 'The lipid flippase ATP10B enables cellular lipid uptake under stress conditions'
