Three-step docking by WIPI2, ATG16L1 and ATG3 delivers LC3 to the phagophore: Molecular dynamics simulation dat
By onAtomistic molecular dynamics simulation data set accompanying manuscript 10.1101/2023.07.17.549391.
Raw band intensity values for ATG3 WT or Mutants in vitro LC3 lipidation
By onRaw band intensity values used for the quantification of in vitro LC3 lipidation results (Fig4C) in 10.1101/2023.07.17.549391
Raw band intensity values for Halo-LC3B
By onSource values referred to raw band intensity used for the quantification of percentage autophagy levels.
Barnes et al (Preprint-03/24) – Datasets
By onDatasets connected to Barnes et al can be found in their preprint publication at https://doi.org/10.21203/rs.3.rs-3982325/v1.
Figure 1: Rubicon KO Starvation and Mitophagy HaloTag processing assay
By onFigure 1. Rubicon depletion promotes bulk autophagy and Parkin mitophagy.
Figure 2. Rubicon and Pacer RH domain have inverted pRAB7A binding specificity [FINAL]
By onFigure 2. Rubicon and Pacer RH domain have inverted pRAB7A binding specificity.
MS proteomics data related to “Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease”
By onMS proteomics data related to "Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease" deposited to the MassIVE repository with the dataset identifier MSV000090202.
metabolomics data related to “Disruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease”
By onNeuromodulation such as deep brain stimulation is advancing as a clinical intervention in neurological and neuropsychiatric disorders, including Parkinson's disease. Here, the authors review current literature in the pre-clinical research fields.
Data and code for “α-Synuclein Overexpression and the Microbiome Shape the Gut and Brain Metabolome in Mice”
By onMetabolomic data and analysis code associated with the article, "α-Synuclein Overexpression and the Microbiome Shape the Gut and Brain Metabolome in Mice."
Identification of phosphorylation sites on NAP1/AZI2
By onThe authors observed smearing for the TBK1-adaptor protein NAP1/AZI2 during mitophagy. Tthe authors performed an in vitro kinase assay and complemented this with the immunoprecipitation of NAP1, resulting in hyperactivation of TBK1.
Raw data of ‘The lipid flippase ATP10B enables cellular lipid uptake under stress conditions’
By onRaw data of 'The lipid flippase ATP10B enables cellular lipid uptake under stress conditions'
Temporal landscape of mitochondrial proteostasis governed by the UPRmt_PRIDE deposition
By onMass spectrometry proteomics data associated with "Temporal landscape of mitochondrial proteostasis governed by the UPRmt" deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD038403.
LRRK2-G2019S Synergizes with Ageing and Low-Grade Inflammation to Promote Gut and Peripheral Immune Cell Activation that Precede Nigrostriatal Degeneration
By onDataset collection related to preprint "LRRK2-G2019S Synergizes with Ageing and Low-Grade Inflammation to Promote Gut and Peripheral Immune Cell Activation that Precede Nigrostriatal Degeneration"
Raw data associated with DOI: 10.7554/eLife.67900 (Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain)
By onImmunofluorescence microscopy images, raw immunoblotting data and tabular data used to generate graphs shown in all figures.
Raw files for Part1: Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain
By onAll data presented in Figure 1, 3, 4 and 5
Data and code for “The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson’s disease mouse model””
By onProcessed data and code for analysis and plotting for the publication "The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson’s disease mouse model"
