Perfusion/ Fixation for cryostat slicing for HHC
By onThis protocol details the Perfusion and Fixation for cryostat slicing for HHC.
Immunohistochemistry of free floating slices
By onThis protocol details the immunohistochemistry of free floating slices.
Collection of protocols for “PINK1 deficiency rewires early immune responses in a mouse model of Parkinson’s disease triggered by intestinal infection”
By onThis a collection of protocols for "PINK1 deficiency rewires early immune responses in a mouse model of Parkinson’s disease triggered by intestinal infection".
The mitochondrial unfolded protein response promotes senescence in human microglia by increasing S-adenosylmethionine availability for polyamine synthesis
By onMitochondria have a response to stress called UPRmt, aiding proteostasis. In humans, UPRmt affects microglia, causing metabolic changes and disrupting communication, leading to dysfunction and inflammation, impacting brain aging and disease.
Mediterranean Diet Adherence, Gut Microbiota and Parkinson’s Disease: A Systematic Review
By onHigh adherence to the Mediterranean diet may improve cognitive function and gastrointestinal symptoms in Parkinson's disease patients, possibly due to changes in gut microbiota. More research is needed to understand its effects on motor symptoms.
Consensus Guidance for Genetic Counseling in GBA1 Variants: A Focus on Parkinson’s Disease
By onThis review discusses the link between *GBA1* and PD, testing practicalities, and counseling approaches.
Glycolipids in Parkinson’s disease: beyond neuronal function
By onGlycolipid balance is crucial for normal body function and its disruption can cause diseases like Parkinson's. Understanding glycolipid pathways can help develop treatments for neurodegenerative diseases like PD.
Data and code for “The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson’s disease mouse model””
By onProcessed data and code for analysis and plotting for the publication "The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson’s disease mouse model"
The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson’s disease mouse model
By onIn this paper, the authors find that the gut microbiome increases mitochondrial respiration and oxidative stress in the brain, which enhances motor symptoms in a mouse model of PD.
Protocol for isolating mitochondria from mouse striatum
By onProtocol used in the Mazmanian lab to isolate striatal mitochondria from mouse for subsequent Seahorse and other analyses
Protocol for mouse striatal tissue dissection, mitochondrial protein extraction, and western blot analysis
By onProtocol used in the Mazmanian lab for preparation and analysis of mitochondrial proteins from the striatum of mouse.
Protocol for quantitative bulk transcriptomics of striatal tissue
By onProtocol used in the Mazmanian lab for quantitative bulk transcriptomics of mouse striatum tissue
