Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
A Blueprint for Training and Development in GP2
This blog written by Dr. Alastair Noyce and Dr. Sara Bandres-Ciga discusses GP2’s plan to train students and investigators and the new considerations as a result of the COVID-19 pandemic.
A letter to the patient community from Randy Schekman, ASAP Scientific Director
This blog written by Dr. Randy Schekman and Benjamin Stecher describes the motivation and beginnings of the ASAP initiative. It also includes a letter written to the PD comunity by Dr. Schekman.
Applying for GP2 Data Access on the AMP® PD Platform
This blog written by Justin C. Solle, Claire Wegel, and Dr. Eline Appelmans outlines how to access GP2 on the AMP PD platform.
Black and African American Connections to Parkinson’s Disease Study: Addressing Missing Diversity in Parkinson’s Disease Genetics
Op-Ed: This article discusses the GP2 Black and African American Connections to Parkinson’s Disease (BLAAC PD) study.
Building Clinical and Genetic Data for GP2 in the Cohort Integration Working Group
This blog written by Dr. Huw Morris describes how the cohort integration working group within GP2 is working to harmonize clinical data.
Decoding the Aliens Within
This blog written by Benjamin Stecher, a patient advocate and author, shows insight into his life as an individual with PD and what genetic insights can provide to understanding PD.
Diversity in Parkinson’s disease genetics research: current landscape and future directions
This review provides an overview of research involving PD genetics in under-represented populations, setting a baseline to measure future impact. The authors found a significant lack of population diversity in PD research, highlighting the need for more representation. This is a preprint.
Evaluating the performance of polygenic risk profiling across diverse ancestry populations in Parkinson’s disease
Objective: This study aims to address disparities in risk prediction by evaluating the performance of polygenic risk score (PRS) models using the 90 risk variants across 78 independent loci previously linked to Parkinson’s disease (PD) risk across seven diverse ancestry populations.
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Themes
Genome-wide association identified novel etiological insights associated with Parkinson’s disease in African and African admixed populations
The authors perform a comprehensive genome-wide assessment of PD in African and African admixed ancestry, characterizing population-specific risk, differential haplotype structure and admixture, coding, structural genetic variation, and polygenic risk profiling. The authors identified a novel common risk factor for PD and age at onset at the GBA1 locus, that was found to be rare in non-African/African admixed populations.
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Themes
Global Parkinson’s Genetics Program Data Release 5
This release includes 7,462 additional new complex disease participants and 487 new monogenic disease participants, adding to the previous releases from the Complex and Monogenic Networks.
Global Parkinson’s Genetics Program data release 6
This release includes >20,000 additional participants adding to the previous releases from the Complex and Monogenic Networks. The complex disease data now consists of a total of 44,831 genotyped participants. The monogenic disease data now consists of a total of 2,324 sequenced participants.
GP2 and AMP PD: Platform Partners for Progress in Parkinson’s Research
This blog written by Hampton Leonard, Dr. Mike Nalls, Matt Bookman, and Dr. Eline Appelmans discusses the partnership between the two initiatives.
GP2 Celebrates the International Day of Women and Girls in Science
This blog written by Dr. Sara Bandres-Ciga highlights women in science within the GP2 network.
