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Evaluating the performance of polygenic risk profiling across diverse ancestry populations in Parkinson’s disease

By Paula Saffie Awad, Inas Elasyed, Arinola O. Sanyaolu, Peter Wild Crea, Artur Francisco Shumacher-Schuh, Kristin S Levine, Dan Vitale, Mathew J Koretsky, Jeffrey Kim, Thiago Peixoto Leal, Sumit Dey, Alastair J Noyce, Armando Palomares Reyes, Noela Rodriguez-Losada, Jia Nee Foo, Wael Mohamed, Karl Heilbron, Lucy Norcliffe-Kaufmann, 23andMe Research Team, Mie Rizig, Njideka Okubadejo, Mike Nalls, Cornelis Blauwendraat, PhD, Andrew Singleton, PhD, Hampton Leonard, Mary B Makarious, Ignacio Mata and Sara Bandres-Ciga

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Description

Objective This study aims to address disparities in risk prediction by evaluating the performance of polygenic risk score (PRS) models using the 90 risk variants across 78 independent loci previously linked to Parkinson’s disease (PD) risk across seven diverse ancestry populations.

Program

Global Parkinson's Genetics Program

Meet the Authors

Paula Saffie Awad

External Collaborator
Inas Elasyed

External Collaborator
Arinola O. Sanyaolu

External Collaborator
Peter Wild Crea

External Collaborator
Artur Francisco Shumacher-Schuh

External Collaborator
Kristin S Levine

External Collaborator
Dan Vitale

External Collaborator
Mathew J Koretsky

External Collaborator
Jeffrey Kim

External Collaborator
Thiago Peixoto Leal

External Collaborator
Sumit Dey

External Collaborator
Alastair J Noyce

External Collaborator
Armando Palomares Reyes

External Collaborator
Noela Rodriguez-Losada

External Collaborator
Jia Nee Foo

External Collaborator
Wael Mohamed

External Collaborator
Karl Heilbron

External Collaborator
Lucy Norcliffe-Kaufmann

External Collaborator
23andMe Research Team

External Collaborator
Mie Rizig

External Collaborator
Njideka Okubadejo

External Collaborator
Mike Nalls

External Collaborator
Cornelis Blauwendraat, PhD

Coalition for Aligning Science
Andrew Singleton, PhD

Global Parkinson's Genetics Program
Hampton Leonard

External Collaborator
Mary B Makarious

External Collaborator
Ignacio Mata

External Collaborator
Sara Bandres-Ciga

External Collaborator