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Genome-wide association identified novel etiological insights associated with Parkinson’s disease in African and African admixed populations
Output Details
Description
Understanding the genetic mechanisms underlying diseases in ancestrally diverse populations is a critical step towards the realization of the global application of precision medicine. Here we perform a comprehensive genome-wide assessment of Parkinson’s disease (PD) in African and African admixed ancestry, characterizing population-specific risk, differential haplotype structure and admixture, coding and structural genetic variation and polygenic risk profiling. We identified a novel common risk factor for PD and age at onset at the GBA1 locus, that was found to be rare in non-African/African admixed populations.
Identifier (DOI)
10.1101/2023.05.05.23289529