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Discover ASAP

The Aligning Science Across Parkinson’s (ASAP) sponsored video series, Discover ASAP, showcases top findings and tools developed across the ASAP network, including datasets, code and software, protocols, and lab materials. Each video features interviews with authors, grantees, and key opinion leaders in Parkinson’s research.

Discover ASAP is designed to further the spread of knowledge and enhance equity across the scientific community by highlighting transparent research practices. We are excited to share these interviews and videos with the research community, with the hope that they will help to accelerate discoveries for Parkinson’s disease.​

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Showing 1-6 of 17


Team
Theme
Year
Topics
Protocol for CRISPR-Based Manipulation and Visualization of Endogenous α-Synuclein in Cultured Mouse Hippocampal Neurons

Protocol for CRISPR-Based Manipulation and Visualization of Endogenous α-Synuclein in Cultured Mouse Hippocampal Neurons

In this episode of Discover ASAP, Leonardo Parra-Rivas, PhD, a project scientist on the Collaborative Research Network (CRN)’s Team Gradinaru, joins us to discuss a protocol for CRISPR-based manipulation and visualization of endogenous α-synuclein in cultured mouse hippocampal neurons.

Check out the publication.

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A Simplified Smell Test to Identify Parkinson’s Disease Using Multiple Cohorts, Machine Learning, and Item Response Theory

A Simplified Smell Test to Identify Parkinson’s Disease Using Multiple Cohorts, Machine Learning, and Item Response Theory

In this episode of Discover ASAP, Juan Li, PhD, a senior clinical research associate on the Collaborative Research Network (CRN)’s Team Schlossmacher, joins us to discuss the development of a simplified smell test to help distinguish patients with Parkinson’s disease from those with other neurological diseases.

Read the publication.

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PyRates: A Code-Generation Tool for Modeling Dynamical Systems in Biology and Beyond

PyRates: A Code-Generation Tool for Modeling Dynamical Systems in Biology and Beyond

In this episode of Discover ASAP, Richard Gast, PhD, a postdoctoral fellow on the Collaborative Research Network (CRN) Team Surmeier, joins us to discuss PyRates, an open-source code-generation tool for modeling dynamical systems across languages.

Check out the publication and explore the tool on GitHub.

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EndoMAP: An Interactive Data Visualization Tool of the Endosomal Structural Interactome

EndoMAP: An Interactive Data Visualization Tool of the Endosomal Structural Interactome

In this episode of Discover ASAP, Miguel Gonzalez-Lozano, a postdoctoral fellow on the Collaborative Research Network (CRN) Team Harper, joins us to discuss EndoMAP, an interactive data visualization tool to explore the structural interactome of the endolysosomal system. 

Check out EndoMAP and the publication. To learn more about the technique used to isolate the lysosomes mentioned by Miguel, check out this publication from Team Harper.

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NeuroBooster Array: A Genome-Wide Genotyping Platform to Study Neurological Disorders Across Diverse Populations

NeuroBooster Array: A Genome-Wide Genotyping Platform to Study Neurological Disorders Across Diverse Populations

In this episode of Discover ASAP, Sara Bandrés-Ciga, Head of Neurogenetics at the Centre for Alzheimer’s and Related Dementias at the National Institutes of Health (NIH) and a researcher in the Global Parkinson’s Genetics Program (GP2), joins us to discuss the NeuroBooster Array, a genotyping array that enables investigation of global genetic variation in neurological conditions.

Check out the publication describing the NeuroBooster Array and the recent publication utilizing the NeuroBooster Array.

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A Fluid-Walled Microfluidic Platform to Study Human Neuron Microcircuitry

A Fluid-Walled Microfluidic Platform to Study Human Neuron Microcircuitry

In this episode of Discover ASAP, Ricardo Márquez Gómez, a postdoc on Collaborative Research Network (CRN) Team Cragg, joins us to discuss their scalable microfluidic platform, created to study human neuron microcircuitry, connectivity, and regeneration in vitro.

Check out the publication.

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Tools & Resources

Our initiative is built upon the idea that supporting collaboration, resource generation, and data sharing will accelerate scientific discovery. We are committed to openly sharing all ASAP contributions, including research outputs, with the research community.

Datasets

Datasets

We are dedicated to ensuring that the datasets we support are accessible to the scientific community so that they can be utilized by others, which may lead to new insights.

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Lab Materials

Lab Materials

We believe that enabling the research community to access and utilize lab materials will accelerate discovery. Check out some of the procedures and resources that we use to support the characterization and distribution of lab materials.

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Protocols

Protocols

We are committed to ensuring that the research community has full access to protocols that we fund so that ASAP-funded research is fully replicable.

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Code & Software

Code & Software

We believe that code and software sharing within the research community is essential to accelerating discoveries. See how all of our ASAP-funded codes and software are shared in a publicly accessible repository.

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