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Discover ASAP

The Aligning Science Across Parkinson’s (ASAP) sponsored video series, Discover ASAP, showcases top findings and tools developed across the ASAP network, including datasets, code and software, protocols, and lab materials. Each video features interviews with authors, grantees, and key opinion leaders in Parkinson’s research.

Discover ASAP is designed to further the spread of knowledge and enhance equity across the scientific community by highlighting transparent research practices. We are excited to share these interviews and videos with the research community, with the hope that they will help to accelerate discoveries for Parkinson’s disease.​

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Showing 1-6 of 20


Team
Theme
Year
Topics
A Programmable Self-Assembling System to Model Intracellular Protein Aggregation

A Programmable Self-Assembling System to Model Intracellular Protein Aggregation

In this episode of Discover ASAP, Yujie Fan, PhD, a postdoctoral fellow on the Collaborative Research Network (CRN)’s Team Gradinaru, joins us to discuss a programmable self-assembling system to model intracellular protein aggregation and decode neurodegenerative diseases.

Check out the preprint.

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AutoMorphoTrack: A Platform for Quantitative Organelle Analysis

AutoMorphoTrack: A Platform for Quantitative Organelle Analysis

In this episode of Discover ASAP, Armin Bayati, PhD, a research fellow on the Collaborative Research Network (CRN)’s Team Chen, joins us to discuss AutoMorphoTrack, a platform for quantitative analysis of organelle morphology, motility, and interactions at single-cell resolution. 

 Check out the preprint and Python package. 

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Automated Quantification of Intracellular Neuromelanin Granules in Human Brain Tissue

Automated Quantification of Intracellular Neuromelanin Granules in Human Brain Tissue

In this episode of Discover ASAP, Anastasia Filimontseva, a graduate student on the Collaborative Research Network (CRN)’s Team Vila, joins us to discuss a standardized, TruAI-based platform for automated quantification of intracellular neuromelanin granules in human brain tissue.

Check out the publication.

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Protocol for CRISPR-Based Manipulation and Visualization of Endogenous α-Synuclein in Cultured Mouse Hippocampal Neurons

Protocol for CRISPR-Based Manipulation and Visualization of Endogenous α-Synuclein in Cultured Mouse Hippocampal Neurons

In this episode of Discover ASAP, Leonardo Parra-Rivas, PhD, a project scientist on the Collaborative Research Network (CRN)’s Team Gradinaru, joins us to discuss a protocol for CRISPR-based manipulation and visualization of endogenous α-synuclein in cultured mouse hippocampal neurons.

Check out the publication.

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A Simplified Smell Test to Identify Parkinson’s Disease Using Multiple Cohorts, Machine Learning, and Item Response Theory

A Simplified Smell Test to Identify Parkinson’s Disease Using Multiple Cohorts, Machine Learning, and Item Response Theory

In this episode of Discover ASAP, Juan Li, PhD, a senior clinical research associate on the Collaborative Research Network (CRN)’s Team Schlossmacher, joins us to discuss the development of a simplified smell test to help distinguish patients with Parkinson’s disease from those with other neurological diseases.

Read the publication.

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PyRates: A Code-Generation Tool for Modeling Dynamical Systems in Biology and Beyond

PyRates: A Code-Generation Tool for Modeling Dynamical Systems in Biology and Beyond

In this episode of Discover ASAP, Richard Gast, PhD, a postdoctoral fellow on the Collaborative Research Network (CRN) Team Surmeier, joins us to discuss PyRates, an open-source code-generation tool for modeling dynamical systems across languages.

Check out the publication and explore the tool on GitHub.

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Tools & Resources

Our initiative is built upon the idea that supporting collaboration, resource generation, and data sharing will accelerate scientific discovery. We are committed to openly sharing all ASAP contributions, including research outputs, with the research community.

Datasets

Datasets

We are dedicated to ensuring that the datasets we support are accessible to the scientific community so that they can be utilized by others, which may lead to new insights.

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Lab Materials

Lab Materials

We believe that enabling the research community to access and utilize lab materials will accelerate discovery. Check out some of the procedures and resources that we use to support the characterization and distribution of lab materials.

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Protocols

Protocols

We are committed to ensuring that the research community has full access to protocols that we fund so that ASAP-funded research is fully replicable.

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Code & Software

Code & Software

We believe that code and software sharing within the research community is essential to accelerating discoveries. See how all of our ASAP-funded codes and software are shared in a publicly accessible repository.

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