LRRK2, lysosome damage, and Parkinson’s disease
By onRecent research has uncovered how LRRK2 kinase activity is regulated by recruitment to endolysosomal membranes, involving interactions with small GTPases and GABARAP. This sheds light on its role in lysosomal damage and Parkinson's disease.
all protocols related to ‘Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and Parkinsonian motor deficits’
By onall protocols related to 'Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and Parkinsonian motor deficits
LRRK2G2019S acts as a dominant interfering mutant in the context of iron overload
By onUsing a model macrophage cell line we showed that LRRK2-G2019S mutation affects iron homeostasis by dysregulating iron-related proteins and blocking ferritinophagy in iron overload conditions, suggesting a role in iron dysregulation in PD.
FSCV dopamine, spike, and LFP data used for validating chronic electrode implanted in aseptic semi-sealed chamber
By onFSCV dopamine, spike, and LFP data used for validating chronic electrode implanted in aseptic semi-sealed chamber in Choi et al. 2025 JNeurosciMethods.
Robust analytical methods for bis(monoacylglycero)phosphate profiling in health and disease
By onBMP is a crucial phospholipid in lysosomes, impacting metabolic balance and linked to neurodegenerative diseases. LC-MS methods are detailed for accurate BMP analysis, utilizing structural differences and a new CLN5 function for profiling.
Choice Reaction Time Reaching Task for Non-human Primate
By onThis protocol describes the behavioral task used with both healthy and MPTP-induced hemiparkinsonian non-human primates in the Turner Lab at the University of Pittsburgh, as well as the training procedure for introducing the task to naïve NHPs.
MatLab Code and Source Data for Analyzing Reach-related Single Unit Activity in the Internal Segment of the Globus Pallidus in Parkinsonian Macaque
By onSource data stored in a non-proprietary format, all MATLAB code, along with histology data prepared for the publication of our study on movement-related activity in the internal globus pallidus of parkinsonian macaques (Kase et al. 2025).
AutoMorphoTrack: An Automated Python Package for Organelle Morphology, Motility, and Colocalization Analysis in Live-Cell Imaging
By onAutoMorphoTrack is a Python package for analyzing organelle dynamics in live-cell imaging data. It automates detection, classification, tracking, and colocalization of mitochondria and lysosomes, enabling reproducible and quantitative analysis.
Needed ASAP: The Partnership Rewiring Neurodegeneration Research
Inside Precision Medicine reports on the new ASAP, Allen Institute, and Michael J. Fox Foundation's partnership to unite Collaborative Research Network (CRN) Cloud data from 3 million human cells across 9 brain regions from individuals with Parkinson’s into the Allen Brain Cell (ABC) Atlas visualization tool, which already contains 6.4 million human cells.
Expanded Research Tool to Crack the Code on Parkinson’s, the Fastest-Growing Neurodegenerative Disease
ASAP and Allen Institute announce a new collaboration that creates a common language for visualizing data from Parkinson’s and Alzheimer’s research
Collaboration Expands Research Tool to Help Crack the Code on Parkinson’s and Other Neurodegenerative Diseases
In this blog, ASAP and Allen Institute answer questions about our new collaboration that helps researchers unlock insights into Parkinson’s and other neurodegenerative diseases.
ASAP Collaborative Research Network (CRN) Impact Report
From 2020 to 2024, the ASAP CRN supported 35 multidisciplinary, international teams across 14 countries. See how the CRN has accelerated breakthroughs in PD research through collaboration and open science.
Charting New Waters in Parkinson’s Research: Highlights From the 2025 CRN Collaborative Meeting
ASAP's 2025 Collaborative Meeting welcomed representatives from our 35 CRN teams to share impactful findings on the PD landscape, promote the cross-fertilization of ideas, and provide opportunities to engage the broader CRN across different levels of training.
Advancing Parkinson’s Disease Research: APDA’s Commitment to Innovation
The American Parkinson Disease Association (APDA) highlights Dr. Roberta Marongiu from CRN Team Kaplitt for her work exploring the role of biological sex in Parkinson’s disease.
Immune Cells May Lead to More Parkinson’s Cases in Men
New research from Team Sulzer reveals how a protein in brain cells may drive Parkinson’s onset—and offers a possible explanation for why Parkinson’s is much more common in men.
Molecular Switch for Toxic Protein Disposal May Be Parkinson’s Target
Parkinson's News Today reports on a new study from CRN Team Hurley that identified a molecular switch in a protein complex that regulates how cellular waste disposal mechanisms clean up and recycle unwanted materials - like the toxic alpha-synuclein protein clumps, or aggregates, that drive the death of nerve cells in Parkinson’s disease.
Protocol Problems: Figuring Out How an Experiment Was Done
Check out this open science blog to understand why ASAP requires a recipe-style protocol or Methods paper to be shared for every Methods section in a manuscript.
2024: A Year in Review
ASAP is excited to share how we pushed the Parkinson’s disease research field forward. Together, our supported programs worked to funnel new ideas into Parkinson’s disease R&D, facilitate the rapid exchange of ideas, ensure researchers can build upon ASAP-funded work, and establish a diverse pipeline for the next generation of researchers.
Celebrating the Collaborative ASAP Community Through Art&Science
Dr. Dorotea Fracchiolla from Team Hurley and Founder of Art&Science shares her recent series of paintings that depict the brains of Parkinson's disease (PD) patients and highlights ASAP's role in facilitating collaboration and knowledge-sharing in the PD community.
PINK1 Pathway to Parkinson’s Disease: 20 Years On
Check out this blog to learn more about the PINK1 meeting that took place in London in November 2024 that marked the 20th anniversary of the discovery of PINK1 mutations linked to Parkinson’s disease.
