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SNCA A30P iPSC
onAvailable at Jax: SNV/WT, REV/WT, and SNV/SNV of the A30P SNCA variant. Associated with Parkinson's disease with dementia. Parental line is KOLF2.1J (JIPSC1000),
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SNCA A53T iPSC
onAvailable at Jax: SNV/WT, REV/WT, and SNV/SNV of the A53T SNCA variant. Associated with Parkinson's disease with dementia. Parental line is KOLF2.1J (JIPSC1000).
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LRRK2 I2020T iPSC
onAvailable at Jax: SNV/WT, REV/WT, and SNV/SNV of the I2020T LRRK2 variant. Associated with Parkinson's disease with dementia. Parental line is KOLF2.1J (JIPSC1000).
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PINK1 A217D iPSC
onAvailable at Jax: SNV/WT, SNV/SNV, and REV/REV of the A217D PINK1 variant. Associated with Parkinson's disease with dementia. Parental line is KOLF2.1J (JIPSC1000).
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LRRK2 N2081D iPSC
onAvailable at Jax: SNV/WT, REV/WT, and SNV/SNV of the N2081D LRRK2 variant. Associated with Parkinson's disease with dementia. Parental line is KOLF2.1J (JIPSC1000).
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PRKN R42P iPSC
onAvailable at Jax: SNV/WT, SNV/SNV, and REV/REV of the R42P PRKN variant. Associated with Parkinson's disease with dementia. Parental line is KOLF2.1J (JIPSC1000).
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PRKN T240M iPSC
onAvailable at Jax: SNV/WT, SNV/SNV, and REV/REV of the T240M PRKN variant. Associated with Parkinson's disease with dementia. Parental line is KOLF2.1J (JIPSC1000).
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SNCA E46K iPSCs
onAvailable at Jax: SNV/WT, Rev/WT, and SNV/SNV of the E46K SNCA variant. Associated with Parkinson's disease with dementia. Parental line is KOLF2.1J (JIPSC1000).
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PRKN R275W iPSC
onAvailable at Jax: SNV/WT, SNV/SNV, and REV/REV of the R275W PRKN variant. Associated with Parkinson's disease with dementia. Parental line is KOLF2.1J (JIPSC1000).
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Regional mouse brain analysis (Modified QUINT)
onThis series of protocols has been adapted from published and unpublished protocols broadly referred to as the QUINT workflow: Note that the original QUINT workflow was generated by Yates and colleagues, and all credit for the development of these programs goes to that team.